Thomas M. Coffman, MD


Professor of Medicine
Professor in Cell Biology
Professor in Immunology
Chief, Division of Nephrology
Department / Division:
Medicine / Medicine-Nephrology
Address:
DUMC 103015
Durham, NC 27710
Appointment Telephone:
919-684-9788
Office Telephone:
919-684-9788
Fax:
919-684-3011
Training:
  • MD, Ohio State University College of Medicine, 1980
Residency:
  • Medicine, Duke University Medical Center, 1980-1983
  • Nephrology, Duke University Medical Center, 1983-1985
Clinical Interests:
Renal transplantation, hypertension
Research Interests:
My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.
Representative Publications:
  • Facemire, CS; Griffiths, R; Audoly, LP; Koller, BH; Coffman, TM. The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background. Hypertension. 2010;55:531-538.  Abstract
  • Gurley, SB; Mach, CL; Stegbauer, J; Yang, J; Snow, KP; Hu, A; Meyer, TW; Coffman, TM. Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice. American Journal of Physiology: Renal Physiology. 2010;298:F788-F795.  Abstract
  • Benigni, A; Corna, D; Zoja, C; Sonzogni, A; Latini, R; Salio, M; Conti, S; Rottoli, D; Longaretti, L; Cassis, P; Morigi, M; Coffman, TM; Remuzzi, G. Disruption of the Ang II type 1 receptor promotes longevity in mice. Journal of Clinical Investigation. 2009;119:524-530.  Abstract
  • Crowley, SD; Vasievich, MP; Ruiz, P; Gould, SK; Parsons, KK; Pazmino, AK; Facemire, C; Chen, BJ; Kim, HS; Tran, TT; Pisetsky, DS; Barisoni, L; Prieto-Carrasquero, MC; Jeansson, M; Foster, MH; Coffman, TM. Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. Journal of Clinical Investigation. 2009;119:943-953.  Abstract
  • Facemire, CS; Nixon, AB; Griffiths, R; Hurwitz, H; Coffman, TM. Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression. Hypertension. 2009;54:652-658.  Abstract
  • Coffman, TM; Crowley, SD. Kidney in hypertension: guyton redux. Hypertension. 2008;51:811-816.  Abstract
  • Gurley, SB; Coffman, TM. The renin-angiotensin system and diabetic nephropathy. Seminars in Nephrology. 2007;27:144-152.  Abstract
  • Coffman, TM. A WNK in the kidney controls blood pressure. Nature Genetics. 2006;38:1105-1106.  Abstract
  • Crowley, SD; Gurley, SB; Herrera, MJ; Ruiz, P; Griffiths, R; Kumar, AP; Kim, HS; Smithies, O; Le, TH; Coffman, TM. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proceedings of the National Academy of Sciences of USA. 2006;103:17985-17990.  Abstract
  • Gurley, SB; Allred, A; Le, TH; Griffiths, R; Mao, L; Philip, N; Haystead, TA; Donoghue, M; Breitbart, RE; Acton, SL; Rockman, HA; Coffman, TM. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. Journal of Clinical Investigation. 2006;116:2218-2225.  Abstract
  • Crowley, SD; Gurley, SB; Oliverio, MI; Pazmino, AK; Griffiths, R; Flannery, PJ; Spurney, RF; Kim, HS; Smithies, O; Le, TH; Coffman, TM. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. Journal of Clinical Investigation. 2005;115:1092-1099.  Abstract
  • Francois, H; Athirakul, K; Howell, D; Dash, R; Mao, L; Kim, HS; Rockman, HA; Fitzgerald, GA; Koller, BH; Coffman, TM. Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metabolism. 2005;2:201-207.  Abstract
  • Goulet, JL; Pace, AJ; Key, ML; Byrum, RS; Nguyen, M; Tilley, SL; Morham, SG; Langenbach, R; Stock, JL; McNeish, JD; Smithies, O; Coffman, TM; Koller, BH. E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. Journal of Immunology. 2004;173:1321-1326.  Abstract
  • Rocha, PN; Plumb, TJ; Coffman, TM. Eicosanoids: lipid mediators of inflammation in transplantation. Springer Seminars in Immunopathology. 2003;25:215-227.  Abstract
  • Tharaux, PL; Bukoski, RC; Rocha, PN; Crowley, SD; Ruiz, P; Nataraj, C; Howell, DN; Kaibuchi, K; Spurney, RF; Coffman, TM. Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. Journal of Immunology. 2003;171:96-105.  Abstract
  • Thomas, DW; Rocha, PN; Nataraj, C; Robinson, LA; Spurney, RF; Koller, BH; Coffman, TM. Proinflammatory actions of thromboxane receptors to enhance cellular immune responses. Journal of Immunology. 2003;171:6389-6395.  Abstract
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